Recurrent Fever

Snyder, Pediatrics (1958),2967 reported on the use of PHT (100-200 mg/day) in eight children with a variety of paroxysmal symptoms including headache, migraine, vertigo, abdominal pain and nightmares. All experienced prompt relief from these symptoms with PHT.In two cases, intermittent fevers of unexplained origin were eliminated by PHT.

2967. Snyder, C. H., Epileptic equivalents in children, Pediatrics, 21: 308-18, 1958.

Berger, Postgraduate Medicine (1966),819 reported on an unusual case of recurrent fever, successfully treated with PHT. A sixteen-year-old boy had irregular attacks of fever for eight years. These attacks would last from four to twenty-four hours, and disappear abruptly, regardless of treatment. His temperature would rise to 102 degrees°F and stay within a degree of this reading until the attack was terminated. Headache, vertigo, weakness, irritability, and sometimes violent rages accompanied the fever. Over a four-year period the patient missed 260 days of school because of these attacks of fever. Extensive tests for causes of fever proved negative. Penicillin, tetracycline and sulfadimethoxine were tried without effect. The patient was treated with 400 mg of PHT per day and the attacks stopped. Subsequently, on a dose of 25 mg q.i.d., he had been free of fever, and the symptoms that accompanied it, for four years. On four occasions PHT was withdrawn. Each time the fever and other symptoms returned within a few days.

819. Berger, H., Fever: an unusual manifestation of epilepsy, Postgrad. Med., 40: 479-481, 1966.

Familial Mediterranean Fever

Hamed, Abdel-Aal, Abdel-Aziz, Nassar, Sweify, Atta, El-Awady, El-Aref and El-Garf, Journal of the Egyptian Medical Association (1975),1879 stated that since 1966 they have used PHT to treat forty-seven children for a periodic disease of unknown etiology, which has many names and which they refer to as familial Mediterranean fever. Thirty-one of the children were available for follow-up. Twenty-two had improvement in the severity and frequency of attacks, six were unimproved and three became worse. The authors conclude that PHT significantly reduces the frequency and severity of attacks of familial Mediterranean fever.

1879, Hamed, M. A., Abdel-Aal, H. M., Abdel-Aziz, T. M., Nassar, S. K., Sweify, S. M., Atta, S. M., El-Awady, S. M., El-Aref, M., El-Garf, A. R., A trial of diphenylhydantoin in periodic disease (farnilial Mediterranean fever) in Egyptian children, J. Egypt. Med. Assoc., 58(3/4): 205-15, 1975.

Transfusion Reaction

Ricevuti, Mazzone, Danesino, Toscano and Rizzo, Lancet (1984),2907 in a study of granulocyte transfusion reactions, noted that six patients pre-treated with PHT did not develop fever; whereas, ten of fifteen non-treated patients did have fever.

2907. Ricevuti, G., Mazzone, A., Danesino, M., Toscano, M., Rizzo, S. C., Phenytoin to prevent or control granulocyte transfusion reactions, Lancet, 37, Jul 7, 1984.

Hypothalamic Syndrome

Bechtereva, Nikitina, Iliuchina, Dambinova and Denisova, European Journal of Clinical Investigation (1984),2316 reported on the use of PHT in 120 patients with hypothalamic syndrome of varying etiologies. PHT (50-100 mg b.i.d. or t.i.d.) resulted in stabilization of body temperature as well as cardiovascular function (including blood pressure) and improvements in mood, sleep and headaches. In the laboratory, PHT was found to inhibit glutaminergic receptor function. The authors suggest that these findings are related to PHT's clinical actions. A number of individuals taking PHT have reported to the Dreyfus Medical Foundation that their usual attacks of "flu," "virus," etc., have been accompanied by less fever than they would have expected. Research in this area seems indicated.

2316. Beebtereva, N. P., Nikitina, L. I., lliuchina, V. A., Dambinova, S. A., Denisova, V. V., Dilantin: clinical and scientific experience of application, Eur. J. Clin. Invest., 14: 36, 1984.