Blank, British Journal of Dermatology (1982),2156 reported his experience with PHT in treating a patient with pachyonychia.

The patient had been incapacitated by blisters and erosions of her feet and hands, and painful lesions in her mouth.

She was treated with oral PHT with dramatic results. She became able to walk for many blocks. Although many of the hyperkeratotic lesions persisted, her mouth and hands were greatly improved. After three years of this treatment she felt so well that she planned to marry.

2156. Blank, H., Treatment of pachyonychia congenita with phenytoin, Br. J. Dermatol., 106(l): 123, 1982.