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Localized Linear Scleroderma
Neldner, Cutis (1978),1994 reported significant reversal of localized linear scleroderma in five patients treated with 100-300 mg PHT daily. The duration of the disease prior to PHT treatment was one to sixteen years. Morbidity included arthralgia and joint stiffness, decreased range of motion, gait disturbances, inability to grasp or throw, alopecia, headache, neuralgias, and neuroses. The most distressing complication was that of deep atrophy beyond the area of linear sclerosis, which produced facial hemiatrophy or atrophy of an entire limb with varying degrees of permanent joint fixation and deep sclerotic bands underlying cutaneous hyperpigmentation. The author states that the response to PHT treatment, and the recurrence of the condition when PHT was prematurely discontinued, point towards the true pharmacologic effect of PHT in the treatment of this disorder.
See also Refs. 1729, 2097, 2297, 2360, 2784, 2953, 3030.
Neldner, H. K., Treatment of localized linear scleroderma with phenytoin,
Cutis, 22: 569-72, 1978.
1729. Asboe-Hansen, G., Treatment of generalized scleroderma: updated results, Acta Derm. Venereol., 59(5): 465-7, 1979.
2097. Swerdlow, M., The treatment of ‘shooting’ pain, Postgrad. Med. J., 56: 159-61, 1980.
2297. Asboe-Hansen, G., Treatment of generalized scleroderma with inhibitors of collagen synthesis, Int. J. Dermatol., 21(3): 159-61, 1982.
2360. Brown, J. J., Murphy, M. J., Transverse myelopathy in progressive systemic sclerosis, Ann. Neurol., 17: 615-17, 1958.
2784. Mehta, M., Chronic pain, Recent Advances in Anaesthesia and Analgesia, Atkinson, R. S. and Hewer, L. C., Eds., Churchill Livingstone, New York, 157-77, 1982.
2953. Siegel, R. C., Scleroderma (systemic sclerosis), Conn’s Current Therapy, Rakel, R. E., Ed., W. B. Saunders Co., Philadelphia, 627-30, 1986.
3030. Tuffanelli, D. L., Scleroderma (systemic sclerosis), Conn’s Current Therapy, Rakel, R. E., Ed., W. B. Saunders Co., Philadelphia, 681-83, 1984.
See also Ref.
3330. Yamanaka, C.T. and Gibbs, N.F., Trauma-induced linear scleroderma, Cutis, 63:29-32, 1999.