Starkova, Marova, Lemesheva, Goncharova, Atamanova and Sedykh, Problemy Endokrinologii (1972), 2090 reported PHT decreased or normalized blood pressure in fifteen hypertensive patients with Cushing’s syndrome.

2090. Starkova, N. T., Marova, E. I., Lemesheva, S. N., Gon charova, V. N., Atamanova, T. M. and Sedykh, L. P., The effect of diphenin on functional condition of the adrenal cortex in patients with Itsenko-Cushing disease, Problemy Endokrinologii, 18: 35-8, Nov/Dec, 1972.

De La Torre, Murgia-Suarez and Aldrete, Clinical Therapeutics (1980),1797 compared PHT with conventional therapy in two groups of forty mildly hypertensive patients and found PHT useful in the reduction of both systolic and diastolic blood pressure. The authors also found PHT more effective in relieving symptoms such as anxiety, headaches, tinnitus, palpitations, chest pain, and dyspnea than the conventional therapy. The authors suggest that PHT provides an alternative antihypertensive therapy, simple compared with most conventional therapies, and with fewer side effects.

1797. de la Torre, R., Murgia-Suarez, J. J. and Aldrete, J. A., Comparison of phenytoin and conventional drug therapy in the treatment of mild hypertension, Clin. Ther., 3(4): 117-24, 1980.

Aldrete and Frantovic, Archives of Surgery (1980),1717 studied changes of arterial blood pressure and heart rate occurring during anesthesia and in the immediate post-operative period in three groups (30 patients each) of hypertensive patients. One group was untreated. A second group received 100 mg of PHT, and the third 200 mg of PHT, the evening before and the morning of surgery. The administration of 200 mg the evening before and on the morning of surgery provided significantly improved hemodynamic stability during surgery.

1717. Aldrete, J. A. and Franatovic, Y., Postponement of operations-its prevention in patients found to be mildly hypertensive, Arch. Surg., 115: 1204-6, 1980.

Kotovskaya and Erina, Biulleten Vsesoiuznogo Kardiologicheskogo Nauchnogo Tsentra AMN SSSR (1982),2668 studied the effects of PHT, pyrroxan and placebo in preventing hypertensive crises in thirty-five patients. In the PHT group (ten patients) there were no crises in five and in three a reduction of frequency and severity of crises was noted.

2668. Kotovskaya, E. S., Erina, E. V., Experiment in the use of neurotropic preparations (diphenylhydantoin and pyrroxan) for the purpose of the crisis-preventive treatment of hypertensive patients, Biull, Vsesoiuznogo Kardiol. Nauchn. Tsentra AMN SSSR, 5(l): 75-9, 1982.

Bechtereva, Nikitina, Iliuchina, Dambinova and Denis ova, European Journal of Clinical Investigation (1984),2316 discussed the use of PHT in treating 120 patients with hypothalamic syndrome. With PHT, blood pressure and body temperature were normalized. In addition there was marked improvement in symptoms such as headache, irritability and feelings of fear. Sleep was also improved.

2316. Beebtereva, N. P., Nikitina, L. I., lliuchina, V. A., Dambinova, S. A., Denisova, V. V., Dilantin: clinical and scientific experience of application, Eur. J. Clin. Invest., 14: 36, 1984.