Temperature Regulation

Gayet-Hallion, Comptes Rendus de la Societe Biologique (1959),2531 reported that PHT (80-100 mg/kg, intraperitoneally) produced a rapid lowering of rat body temperature (approximately 5 degrees). A similar effect was observed in guinea pig.

2531. Gayet-Hallion, T., On the temperature-reducing properties of diphenylhydantoin, Compt. Rend. Soc. Biol., 153: 760-1, 1959.

Lotti, Torchiana and Porter, Archives Internationales de Pharmacodynamie et de Therapie (1973),1306 found that PHT (17 mg/ kg) offset lowered body temperature and suppression of locomotion induced by reserpine in mice.

1306. Lotti, V. J., Torchiana, M. L., and Porter, C. C., Investigations on the action and mechanism of action of diphenylhydantoin as an antagonist of tetrabenazine and reserpine, Arch. Int. Pharmacodyn., 203: 107-116, 1973.

Korczyn, Shavit and Schlosberg, European Journal of Pharmacology (1980),1932 reported that PHT (5 mg/kg), as well as dantrolene sodium and procaine, reduced mortality from succinyleholine-induced malignant hyperpyrexia in chicks. Mortality in PHT-treated chicks was 27%, compared to 66% in the control group. The authors suggest that PHT's protective effects are due to its prevention of excessive intracellular calcium accumulation.

1932. Korczyn, A. D., Shavit, S. and Schlosberg, I., The chick as a model for malignant hyperpyrexia, Eur. J. Pharmacol., 61: 187-9, 1980.

Sechi, Melis, Caria, Tanca and Rosati, Advances in Epileptology (1989),3690 reported that ketamine-induced flexor rigidity was suppressed in rats 30 min after oral administration of PHT. The authors state that PHT's ability to counteract the rigidity induced by ketamine suggests a possible therapeutic role of PHT in hyperthermia, which is sometimes induced by ketamine or phencyclidine and always sustained by muscular rigidity.

3690. Sechi, G.P., Melis, F., Caria, M.A., Tanca, S., and Rosati, G., Ketamine may interact with phenytoin at a pharmacokinetic and a pharmacodynamic level, Adv. Epileptol., 17: 185-88, 1989.

See also Clinical: Fever and Temperature Regulation.

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