Sleep

Cohen, Duncan and Dement, Electroencephalography and Clinical Neurophysiology (1968),58 studied the effect of PHT (9 mg/kg, daily) on the sleep patterns of cats. PHT decreased rapid eye movement (REM) sleep time significantly. REM periods were both shorter and less frequent. There was no consistent change in any non-REM sleep time.

58. Cohen, H. B., Duncan, R. F., II, and Dement, W. C., The effect of diphenylhydantoin and sleep in the cat, Electroenceph. Clin. Neurophysiol., 24: 401-408, 1968. 

Zung, Psychophysiology (1968),397 studied the effects of PHT on sleep in ten adults, between the ages of twenty and forty-six, using all-night EEG and EOG (electrooculogram) recordings. Comparison between control and drug nights indicated that, with PHT, the time spent in REM sleep was significantly decreased, and non-REM sleep was increased.

397. Zung, W. W. K., Effect of diphenylhydantoin on the sleep-dream cycle: an EEG study in normal adults, Psychophysiology, 5: 206, 1968.

Wolf, Roder-Wanner and Brede, Epilepsia (1984),3080 studied polygraphic sleep patterns (EEG, EOG, ECG and respiration) in forty epileptic patients who were not on any medication. They compared phenobarbital and PHT in a randomized crossover design. With both phenobarbital and PHT sleep onset came sooner, but with PHT light sleep was decreased and deep sleep increased. The authors state, "The decrease of light to the benefit of deep sleep, together with the rapid sleep onset, make PHT look like an excellent sleeping medication." In addition, they comment that few patients report sleep hangovers with PHT.

3080. Wolf, P., Roder-Wanner, U. U., Brede, M., Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy, Epilepsia, 25(4); 467-75, 1984.

Declerck, Martens and Wauquier, Neuropsychobiology (1985),2445 studied the effects of one night's sleep deprivation on sleep patterns in normal individuals and in epileptic patients. In the patients taking PHT, the authors found increased non-REM sleep, decreased eye movements during REM sleep and an overall stabilized sleep pattern.

2445. Declerek, A. C., Martens, W. L., Wauquier, A., Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following one night total sleep deprivation in epileptic patients, Neuropsychobiology, 13: 201-05,1985.

See also Clinical: Thought, Mood and Behavior section and Refs. 2777, 3079. 

2777. Maxion, H., Jacobi, P., Schneider, E., Kohler, M., Effect of the anticonvulsant drugs primidone and diphenylhydantoin on night sleep in healthy volunteers and epileptic patients, Sleep 1974. 2nd Europ. Congr. on Sleep Research, Koella, W. P. and Levin, P. Eds., Karger, Basel, 510-13, 1975.
3079. Wolf, P., Influence of the anti-epileptic drugs on sleep, 16th Epilepsy Congress, Abstracts, Hamburg, Ciba-Geigy, 1985.

See also Refs.

3635. Declerck, A.C. and Wauquier, A., Influence of antiepileptic drugs on sleep patterns, Epilepsy Res. Suppl., 2: 153-163, 1991.

3636. Sammaritano, M. and Sherwin, A., Effect of anticonvulsants on sleep, Neurology, 54(1):S17-S24, 2000.

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