Lason, Przewlocka and Przewlocki, Life Sciences (1985),2691 studied the effects of a group of substances, including PHT, on beta-endorphin and dynorphin levels in rat hypothalamus, pituitary, hippocampus and thalamus. PHT (10 mg/kg) decreased the concentrations of beta-endorphin, but not dynorphin, in the hypothalamus. The authors suggest that the release of beta-endorphin induced by low doses of PHT may account for its therapeutic effects in affective disorders.

2691. Lason, W., Przewlocka, B., Przewlocki, R., The effect of Gamma-hydroxybutyrate and anticonvulsants on opioid peptide content in the rat brain, Life Sci., 33(l): 599-602, 1983.