Other Pituitary Hormones

Takahashi, Kipnis and Daughaday, Journal of Clinical Investigation (1968),487 found, in humans, that growth hormone secretion during sleep was not affected by PHT.

487. Takahashi, Y., Kipnis, D. M., and Daughaday, W. H., Growth hormone secretion during sleep, J. Clin. Invest., 47: 2079-2090, 1968.

Mittler and Glick, Abstracts of the Fourth International Congress on Endocrinology (1972),1368 studied the effect of PHT (40 µg/ml) on the release of oxytocin from isolated rat pituitary gland. Increasing potassium in the medium increased oxytocin release. Preincubation with PHT reduced this stimulated release of oxytocin by 35%.

1368. Mittler, J. C. and Glick, S. M., Radioimmunoassayable oxytocin release from isolated neural lobes: responses to ions and drugs, Abstracts Fourth lnt. Cong. Endocr., 47, June, 1972.

Guzek, Russell and Thorn, Acta Pharmacologica et Toxicologica (1974),1105 demonstrated that PHT (40 µg/ml) inhibits the release of vasopressin from isolated rat neurohypophysis. The effect was observed both during release conditions and, after electrical stimulation of the hypophysis. The authors note that their observations are relevant to the other situations in which PHT has been shown to have a regulatory effect on release of insulin, glucagon and calcitonin.

1105. Guzek, J. W., Russell, J. T., and Thorn, N. A., Inhibition by diphenylhydantoin of vasopressin release from isolated rat neurohypophyses, Atia Pharmacol. et Toxicol., 34: 1-4, 1974.

Chalmers and Johnson, Journal of Neurology, Neurosurgery and Psychiatry (1983),2383 found that PHT (500 mg the evening prior to testing) increased human growth hormone levels induced by thirty-minute exercise.

2383. Chalmers, R. J., Johnson, R. H., The effect of diphenylhydantoin on metabolic and growth hormones during and after exercise., J. Neurot. Neurosurg. Psychiatry, 46(7): 662-65,1983.